Fig 1: Double immunogold labeling of chromatin (a) and the strands (b) with antibodies to dsDNA (10 nm gold particles) and LEMD2 (15 nm gold particles, some additionally enhanced using arrows); (c) counting of the labeling density of different GV parts. Despite the fact that LEMD2 is distributed throughout the GV, it concentrates in the strand-containing parts of the nucleoplasm (****, p < 0.0001); differences between other parts of the GV are not so significant (*, p < 0.05).